As part of Charles University's constant efforts to develop and strengthen its research base, we are keen to recruit high-quality post-doctoral research fellows from abroad to work at top University or faculty centres and contribute to the University's strong research profile. The goal of the International Post-Doc Research Fund is to attract promising post-docs who will carry out research within a specific field. Selection is carried out by the relevant research centre or department of the faculty responsible for the research. The post-doc research fellow is recruited to work on the research project for a period of two years. The applicant must have received a PhD degree no more than 10 years prior to the application deadline.
For the year 2015 the deadline for submitting the applications to 2nd Faculty of Medicine, Charles University in Prague is August 25th 2014.
2nd Faculty of Medicine lists these research projects:
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Alternations of radical burden and kinase cascades in the mechanism of chronic hypoxic pulmonary hypertension
Pulmonary hypertension represents a group of diseases with a devastating prognosis. Despite a considerable progress in therapy over the past two decades, there remains more than 50% of patients who continue to have very poor quality of life. Chronic hypoxia is a well recognized strong pathogenetic factor (it elicits pulmonary hypertension by itself). Both changes in active vascular tone (and its reactivity) and morphological remodeling of the vascular wall participate in the mechanism of chronic hypoxic pulmonary hypertension. There is little doubt that both production and scavenging of reactive oxygen species are altered in pulmonary hypertension and this contributes to its mechanism. However, given the technical difficulties in studying these unstable substances, their role is poorly understood. Recently, the role of altered Rho kinase pathway has been firmly established, however, the role of other kinase cascades in pulmonary hypertension is unknown, although there are data indicating that changes in other kinase systems (e.g. Src tyrosine kinase) may play an important role in vasoconstrictor reactivity and remodeling of pulmonary hypertension. The aim of this call is to shed light on these therapeutically promising possibilities.
Contact:
prof. RNDr. Václav Hampl, DrSc.
Department of Physiology, Second Faculty of Medicine
Charles University in Prague
@email
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Evolution of bacterial genome during the chronic infection with Burkholderia cenocepacia in patients with the cystic fibrosis
Contact:
doc. MUDr. Pavel Dřevínek, CSc.
Department of Medical Microbiology, Second Faculty of Medicine
Charles University in Prague
@email
For more information and application forms:
http://www.cuni.cz/UKEN-178.html
