Krejcova L, Fabrik I, Hynek D, Krizkova S, Gumulec J, Ryvolova M, Adam V, Babula P, Trnkova L, Stiborova M, Hubalek J, Masarik M, Binkova H, Eckschlager T, Kizek R. Int. J. Electrochem. Sci., 7 (2012) 1767–1784. IF: 3.729
Department of Paediatric Haematology and Oncology
Abstract
There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. The most important objective of this study is the electrochemical monitoring of metallothionein levels in patients with primary malignant tumors in head and neck examination and the suitability of electrochemical detection as a technique used in clinical practice. In conclusion, MT levels are closely associated with the rate of tumour differentiation, stage of tumour disease and tumour cell characteristics. Our study demonstrates not only changes in blood MT levels in patients suffering from malignant tumour disease in head and neck area, but also suitability of electrochemical techniques for blood analysis.
Malignant tumors of the head and neck are serious health problems. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (MT) levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction.
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