Vit Neuman; Lukas Plachy; Lenka Drnkova; Stepanka Pruhova; Stanislava Kolouskova; Barbora Obermannova; Shenali A Amaratunga; Klara Maratova; Michal Kulich; Jaroslav Havlik; David Funda; Ondrej Cinek; Zdenek Sumnik | Diabetes Research and Clinical Practice | Nov 2024 | IF: 6.1 | doi.
MUDr. Vít Neuman, Ph.D., Department of Paediatrics, Second Faculty od Medicine and Motol University Hospital
Abstract
Aims
We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD).
Methods
Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female; 20 CSII; age 14.5 ± 2.9 years; HbA1c 48.9 ± 9.4 mmol/mol). The interventions were five and five weeks of ready-made food box deliveries of isocaloric diets in random order: either LCD (94.5 ± 4.7 g/day) or recommended carbohydrate diet (RCD) (191 ± 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data.
Results
Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, P=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects’ body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL.
Conclusions
Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.
