Richard Skaba, Vojtech Dotlacil, Pavla Fuccillo, Blanka Rouskova, Lucie Pos, Michal Rygl. European Journal of Pediatric Surgery. November 2023. doi
![prof. MUDr. Richard Škába, CSc.](/files/styles/medium/public/images/publication/2023/skaba.jpg?itok=jMNEO_3w)
Prof. MUDr. Richard Škába, CSc., Department of Paediatric Surgery, Second Faculty of Medicine and Motol University Hospital
Abstract
Introduction: Postoperative constipation (PC) in patients with imperforate anus and perineal fistula (PF) has been reported in up to 60%. Histological studies of PF revealed innervation anomalies which seem to be one of the reasons for PC. Perioperative histologically controlled fistula resection (PHCFR) allows appropriate resection of PF and pull-down normoganglionic rectum at the time of posterior sagittal anorectoplasty (PSARP).
Materials and methods: A total of 665 patients with anorectal malformations underwent surgery between 1991 and 2021. Of these, 364 presented PF; 92 out of them (41 F) were studied. Patients with sacral and spinal cord anomalies, neurological disorders, and cut-back anoplasty were excluded. PSARP was done on all patients. Hematoxylin-eosin staining and NADH Tetrazolium-reductase histochemical method were used. Four and more ganglion cells in the myenteric plexus represented a sufficient length of the resection. The continence was scored according to the modified Krickenbeck scoring system. Final scores ranged from 1 to 7 points. Values are given as median.
Results: A total of 65 (70.7%) patients presented an aganglionic segment in PF, and 27 patients presented hypoganglionosis. The median length of the resected fistula was 25 mm (interquartile range [IQR]: 20-30). The median total continence score was 7 (IQR: 6-7). Post-op constipation was observed in 6/92 (6.5%) patients.
Conclusion: PHCFR diminished PC to 6.5% of patients.