Formankova R, Sedlacek P, Keslová P, Sramkova L, Zizkova H, Stary J. Leuk Lymphoma. 2010 Oct;51(10):1936–40. IF: 2.397
Abstract:
Relapse of acute leukemia (AL) remains a major cause of treatment failure in allogeneic hematopoietic stem cell transplantation (HSCT) in children. Current treatment options include chemotherapy (CHT), adoptive immunotherapy (AI) and second allogeneic transplantation. Between January 1994 and December 2007 a total of 132 children with acute leukemia were transplanted at our institution. Post-transplant relapse of AL following first allogeneic HSCT was documented in 42 patients, intensive treatment of hematological relapse was initiated in 20 patients. Twelve patients underwent second allogeneic HSCT. We showed that second HSCT in pediatric patients was well tolerated and that it is a reasonable option for the treatment of children with relapse of acute leukemia after the first allogeneic transplant.
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